FACULTY PROFILE
Dr. V RAMAKRISHNA
Assistant Professor
Dept. of Biotechnology & Bioinformatics
Yogi Vemana University
KADAPA – 516003. A.P
+91 9866016961
vrkbtbi@yogivemanauniversity.ac.in
vrkrishna70@gmail.com
Qualification :
M. Sc., Ph. D in Biochemistry
Work experience (PDF/Teaching etc.):
Post-Doctoral Experience
1. Penn State University, State College, PA, USA (2012 – 2013) – Obesity induced colorectal cancer prevention through Indian gooseberry bioactives – Omic study.
2. Colorado State University, Fort Collins, CO, USA (2012 – 2013) – Obesity induced colorectal cancer prevention through Indian gooseberry bioactives – Omic study.
3. University of Hyderabad, Hyderabad, India (2007-09) – Role of Bioactives on DNA damage and repair in neuroblastoma cells, and also in rat liver and kidney mitochondrial diseases.
Teaching experience – 20 Years
1. Assistant Professor in BLDEA’s Medical college, Bijapur – 5 Years
2. Assistant Professor in Sri Krishnadevaraya University, Anantapur – 3.5 years
3. Assistant Professor in Yogi Vemana University, Kadapa – 9 Years and continuing
4. Lecturer in Private PG Colleges – 3 years
Area of Research Interest:
  • Functional Foods in prevention of cancer, diabetes, and infectious diseases.
  • Polypharmacology’ of bioactive compounds in drug discovery.
  • Bioinformatics

Cancer, diabetes and infectious diseases are the leading diseases posing a serious demographic and economic burden worldwide. Available drugs combat these diseases with strenuous side effects and need for a development of effective safe drugs. As Hippocrates (father of medicine) quoted “Let food be thy medicine and medicine be thy food” and Ayurveda told “Let food be your medicine”. Indian cuisine encompasses a wide variety of regional cuisines native to India with locally available spices, herbs, vegetables and fruits. This diet is having rich sources of bioactive compounds, lead molecules for safe drug discovery. Our laboratory uses in vitro, in vivo and in silico models to explore the role of dietary bioactive compounds in both the development and prevention of cancer, diabetes and infectious diseases through ‘polypharmaocology’ approach.
Goal of Dr. Ramakrishna research is to optimize the health profiles of food products and provide “Modern Evidence for Ancient Wisdom on Diet in prevention of diseases”.
Research grants (during the last Five years) :
1. DST major project – Rs.34 lakhs - Investigation of neuroprotective agents from Ficus religiosa extracts against oxidative stress induced DNA damage and repair mechanisms in neuroblastoma cells.
2. DBT (Biotechnology Overseas Associateship) – Rs. 24 lakhs - Obesity enhanced colorectal cancer prevention through Amla bioactive molecules – A molecular approach.
Research students (Ph.D awarded/working):
Ph.D. Awarded
1. Eadlapalli Siddhartha
Ph.D. Working
1. M. Suresh kumar Reddy
2. Manoj Kumar Gupta
Awards and achievements :
1. DBT CREST Award (Cutting-edge Research Enhancement and Scientific Training) – Govt. of India (2012)
2. DBT CREBB Award – Govt. of India (2008)
3. UGC – JRF & SRF fellowships (1993)
Selected publications :
1. Manoj Kumar Gupta#, Ramakrishna Vadde#, Ravindra Donde, & Lambodar Behera (2018). Insights into the structure–function relationship of Brown Plant Hopper resistance protein, Bph14 of rice plant: A Computational Structural Biology Approach. Journal of Biomolecular Structure and Dynamics, DOI: 10.1080/07391102.2018.1462737. #Equal contribution first authors. IF – 3.107
2. Ramakrishna Vadde, V. Sarojamma, J. Rajeswari, Pallavula V Bramhachari, Ganji P Nagaraju (2017). Role of Hypoxia-inducible factors (HIF) in the maintenance of stemness and malignancy of colorectal cancer. Critical Reviews in Oncology/Hematology 113, 22–27. http://dx.doi.org/10.1016/j.critrevonc.2017.02.025. IF – 4.495
3. Manojkumar Gupta, Santosh kumar B, V. Ramakrishna (2017). In silico analysis of differential gene expressions in biliary stricture and hepatic carcinoma. Gene 15; 597:49-58. DOI. 10.1016/j.gene.2016.10.032 *Corresponding author. IF – 2.498
4. Ramakrishna Vadde, Sridhar Radhakrishnan, Lavanya Reddivari, Jairam K.P. Vanamala (2016). Indian gooseberry (Emblica officinalis Gaertn.) suppresses cell proliferation and induces apoptosis in human colon cancer stem cells independent of p53 status via suppression of c-Myc and cyclin D1. Journal of Functional Foods 25; 267–278. IF – 3.767
5. Charepalli V, Reddivari L, Vadde Ramakrishna, Suresh, W, Radhakrishnan S, Vanamala JK. (2016). Eugenia jambolana (Java Plum) Fruit Extract Exhibits Anti-Cancer Activity against Early Stage Human HCT-116 Colon Cancer Cells and Colon Cancer Stem Cells. Cancers 2016, 8, 29; doi:10.3390/cancers8030029. IF – 5.326
6. Charepalli V, Reddivari L, Radhakrishnan S, Vadde R, Agarwal R, Vanamala JK. (2015). Anthocyanin-containing purple-fleshed potatoes suppress colon tumorigenesis via elimination of colon cancer stem cells. Journal of Nutritional Biochemistry. Volume 26, Issue 12, Pages 1641–1649. doi: 10.1016/j.jnutbio.2015.08.005. IF – 4.669
7. Ramakrishna V, Radhakrishnan S, Reddivari L, Jairam KP Vanamala (2015). Triphala extract suppresses proliferation and induces apoptosis in human colon cancer stem cells via suppressing c-Myc/cyclin D1 and elevation of Bax/Bcl-2 ratio. BioMed Research International, Vol 2015, Article ID 649263. dx.doi.org/10.1155/2015/649263 IF – 2.583
8. Vadde Ramakrishna, Sriram Gopi and Oruganti H Setty (2012). Protective effect of Hemidesmus indicus extract against bromobenzene induced mitochondrial dysfunction in rat kidney. American J Chinese Medicine 40 (3): 567-80. IF – 3.12
9. Vadde Ramakrishna, S Rajasekhar and L. Sudarsana Reddy (2010). Isolation and purification of metalloprotease from grass pea (Lathyrus sativus) seeds. Applied Biochemistry and Biotechnology, 160: 63–71. IF – 1.797
10. Vadde Ramakrishna, V. Sarojamma, and L. Sudarsana Reddy (2009). Short report - Genetic predisposition to chikungunya – a blood group study in chikungunya affected families. Virology Journal, 6:77. IF -2.465
11. Vadde Ramakrishna and Rama Jailkhani (2008). Oxidative stress in non-insulin dependent diabetes mellitus (NIDDM) patients. Acta Diabetologica 45(1): 41. IF – 3.126
Conference/symposia attended (during the last five years):
25
Conference/symposia organized (during the last five years):
3
Other Information (books, patents, collaborations etc.):
1. Dr. Julien Y. Dutheil, Max Planck Institute for Evolutionary Biology Molecular Systems Evolution Department of Evolutionary Genetics Plön -- GERMANY
2. Dr. Jairam KP Vanamala, Dept. of Food Science, Penn State University, University-Park, State College, PA, USA