FACULTY PROFILE
Dr. VADDE RAMAKRISHNA
Assistant Professor & Co-ordinator
Dept. of Biotechnology & Bioinformatics
+91 9866016961
vrkbtbi@yogivemanauniversity.ac.in , vrkrishna70@gmail.com
Qualification :
M. Sc Biochemistry
Ph. D Biochemistry
Work Experience :
Post-Doctoral Experience : 3 Years
Pennsylvania State University, State College, PA, & Colorado State University, Fort Collins, CO, USA (2012 – 2013) – Obesity induced colorectal cancer prevention through Indian gooseberry bioactives – Omic study.
University of Hyderabad, Hyderabad, India (2007-09) – Role of Bioactives on DNA damage and repair in neuroblastoma cells, and also in rat liver and kidney mitochondrial diseases.
Teaching experience : 16 Years
(Taught Biochemistry, Biotechnology & Bioinformatics) at
BLDEA Medical College, Bijapur (5 Years)
Sri Krishnadevaraya University, Anantapur (3.5 Years)
Yogi Vemana University, Kadapa (2009 – to date)
Area of Research Interest:
Bioactive compounds for health and diseases,
Food based approach to prevent chronic diseases
Protein biochemistry and Bioinformatics
Goal of my research is to optimize the health profiles of food products and provide “Modern Evidence for Ancient Wisdom on Diet in prevention of diseases”.
(BIOACTIVE COMPOUNDS FOR HEALTH: Cancer and infectious diseases are the leading diseases posing a serious demographic and economic burden worldwide. Available drugs combat these diseases with strenuous side effects and need for a development of effective safe drugs. As Hippocrates (father of medicine) quoted “Let food be thy medicine and medicine be thy food” and Ayurveda told “Let food be your medicine”. Indian cuisine encompasses a wide variety of regional cuisines native to India with locally available spices, herbs, vegetables and fruits. This diet is having rich sources of bioactive compounds, lead molecules for safe drug discovery. Our laboratory uses animal, cell and in silico models to explore the role of dietary bioactive compounds in both the development and prevention of cancer and infectious diseases. In particular, we examine how dietary bioactive components alter molecular signaling pathways, omics study, identification of lead molecule and effective drug design by using bioinformatics tools. The long-term goal of my research is to optimize the health profiles of Indian food products and provide modern evidence for ancient wisdom on diet and disease.)
Research Grants :
DST major project – Rs.34 lakhs - Investigation of neuroprotective agents from Ficus religiosa extracts against oxidative stress induced DNA damage and repair mechanisms in neuroblastoma cells.
DBT (Biotechnology Overseas Associateship) – Rs. 25 lakhs - Obesity enhanced colorectal cancer prevention through Amla bioactive molecules – A molecular approach.
AgrisciencePark, A.P – Miniproject- Antibacterial effect of Amla extract against ESBL (Extended Spectrum of β-lactamases) producing multidrug resistant bacteria.
Research students (Ph.D awarded/working):
1. Eadlapalli Siddhartha
2. M. Suresh Kumar Reddy
3. Manoj Kumar Gupta
Awards and achievements :
DBT CREST Award (Cutting-edge Research Enhancement and Scientific Training) – Govt. of India (2011)
DBT CREBB Award – Govt. of India (2008)
UGC – JRF & SRF fellowships (1993)
Conference/symposia
attended :
International conferences – 8
National conferences – 34
Total = 42
organized:
National conferences organized - 3.
Selected Best Publications :
  1. V. Ramakrishna, S. Radhakrishnan, HKK Eranda, Reddivari L, Jairam K.P. Vanamala (2016). Indian gooseberry (Emblica officinalis Gaertn.) suppresses cell proliferation and induces apoptosis in human colon cancer stem cells independent of p53 status via suppression of c-Myc and cyclin D1. Journal of Functional Foods 25; 267–278.
  2. Charepalli V, Reddivari L, Ramakrishna V, Suresh, W, Radhakrishnan S, Vanamala JK. (2016). Eugenia jambolana (Java Plum) Fruit Extract Exhibits Anti-Cancer Activity against Early Stage Human HCT-116 Colon Cancer Cells and Colon Cancer Stem Cells. Cancers 2016, 8, 29; doi:10.3390/cancers8030029
  3. Charepalli V, Reddivari L, Ramakrishna V, Radhakrishnan S, Agarwal R, Vanamala JK. (2015). Anthocyanin-containing purple-fleshed potatoes suppress colon tumorigenesis via elimination of colon cancer stem cells. Journal of Nutritional Biochemistry. Volume 26, Issue 12, Pages 1641–1649.
  4. Shaik JB, Palaka BK, Penumala M, Kotapati KV, Devineni SR, Eadlapalli S, Darla MM, Ampasala DR, Ramakrishna V, Amooru GD. (2016). Synthesis, pharmacological assessment, molecular modeling and in silico studies of fused tricyclic coumarin derivatives as a new family of multifunctional anti-Alzheimer agents. Euro J Medicinal Chemistry, 107(1): 219-232. doi: 10.1016/j.ejmech.2015.10.046.
  5. Ramakrishna V, Radhakrishnan S, Reddivari L, Jairam KP Vanamala (2015). Triphala extract suppresses proliferation and induces apoptosis in human colon cancer stem cells via suppressing c-Myc/cyclin D1 and elevation of Bax/Bcl-2 ratio. BioMed Research International, Vol 2015, Article ID 649263. http://dx.doi.org/10.1155/2015/649263
  6. V. Ramakrishna, Sriram Gopi and Oruganti H Setty (2012). Protective effect of Hemidesmus indicus extract against bromobenzene induced mitochondrial dysfunction in rat kidney. American J Chinese Medicine 40 (3): 567-80.
  7. Nirmal K Prasad, Vaibhav Vindal, Siva Lakshmi Narayana, and V. Ramakrishna (2011). In silico analysis of Pycnoporus cinnabarinus laccase active site with toxic industrial dyes. Journal of Molecular Modeling 18(5): 2013-19.
  8. Rajeswari Jinka, Ramakrishna V, Sridhar Rao Kunchala and Ramakrishna Rao Pillutla (2009). Purification and characterization of cysteine protease (CPR HG) from germinating cotyledons of Horse gram. BMC Biochemistry, 10:28.
  9. V. Ramakrishna, and V Sarojamma (2008). Connective tissue metabolism in chikungunya patients. Virology Journal 5: 31.
  10. V. Ramakrishna and Rama Jailkhani (2008). Oxidative stress in non-insulin dependent diabetes mellitus (NIDDM) patients. Acta Diabetologica 45(1): 41.
Any specific inclusions (books, patents, collaborations etc.):
1. Scientific Advisory Board member for Biostandups website http://www.biostandups.com/advisory-board/
2. Collaboration with Dr Jairam K P Vanamala’s laboratory, Penn State University, State College, PA, USA.