Assistant Professor
Dept. of Biotechnology & Bioinformatics
+91 9866016961
Qualification :
M. Sc., Ph. D in Biochemistry
Work experience (PDF/Teaching etc.):
20 Years
Area of Research Interest:
Food based approach to prevent cancer, diabetes and infectious diseases.
Polypharmacology of bioactive compounds in drug discovery.
Cancer, diabetes and infectious diseases are the leading diseases posing a serious demographic and economic burden worldwide. Available drugs combat these diseases with strenuous side effects and need for a development of effective safe drugs. As Hippocrates (father of medicine) quoted “Let food be thy medicine and medicine be thy food” and Ayurveda told “Let food be your medicine”. Indian cuisine encompasses a wide variety of regional cuisines native to India with locally available spices, herbs, vegetables and fruits. This diet is having rich sources of bioactive compounds, lead molecules for safe drug discovery. Our laboratory uses in vitro, in vivo and in silico models to explore the role of dietary bioactive compounds in both the development and prevention of cancer, diabetes and infectious diseases through ‘polypharmaocology’ approach.
Goal of Dr. Ramakrishna research is to optimize the health profiles of food products and provide “Modern Evidence for Ancient Wisdom on Diet in prevention of diseases”.
Research grants (during the last Five years) :
  1. DST major project – Rs.34 lakhs - Investigation of neuroprotective agents from Ficus religiosa extracts against oxidative stress induced DNA damage and repair mechanisms in neuroblastoma cells.
  2. DBT (Biotechnology Overseas Associateship) – Rs. 24 lakhs - Obesity enhanced colorectal cancer prevention through Amla bioactive molecules – A molecular approach.
Research students (Ph.D awarded/working):
Ph.D. Awarded
1. Eadlapalli Siddhartha
Ph.D. Working
1. M. Suresh kumar Reddy
2. Manoj Kumar Gupta
Awards and achievements :
  1. DBT CREST Award (Cutting-edge Research Enhancement and Scientific Training) – Govt. of India (2012)
  2. DBT CREBB Award – Govt. of India (2008)
  3. UGC – JRF & SRF fellowships (1993)
Selected publications :
  1. Ramakrishna Vadde, V. Sarojamma, J. Rajeswari, P V Bramhachari, Ganji P Nagaraju (2017). Role of Hypoxia-inducible factors (HIF) in the maintenance of stemness and malignancy of colorectal cancer. Critical Reviews in Oncology/Hematology 113, 22–27. http://dx.doi.org/10.1016/j.critrevonc.2017.02.025.
  2. Manojkumar Gupta, Santosh kumar B, and Vadde Ramakrishna (2017). In silico analysis of differential gene expressions in biliary stricture and hepatic carcinoma. Gene 15;597:49-58. DOI. 10.1016/j.gene.2016.10.032
  3. Ramakrishna Vadde, Sridhar Radhakrishnan, Hewage Eranda Karunathilake Kurundu, Lavanya Reddivari, Jairam K.P. Vanamala (2016). Indian gooseberry (Emblica officinalis Gaertn.) suppresses cell proliferation and induces apoptosis in human colon cancer stem cells independent of p53 status via suppression of c-Myc and cyclin D1. Journal of Functional Foods 25; 267–278
  4. Lavanya Reddivari, Venkata Charepalli, Sridhar Radhakrishnan, Ramakrishna Vadde, Ryan J. Elias, Joshua D. Lambert and Jairam K. P. Vanamala. (2016). Grape compounds suppress colon cancer stem cells in vitro and in a rodent model of colon carcinogenesis. BMC Complementary and Alternative Medicine 2016 16:278
  5. Ramakrishna V, Radhakrishnan S, Reddivari L, Jairam KP Vanamala (2015). Triphala extract suppresses proliferation and induces apoptosis in human colon cancer stem cells via suppressing c-Myc/cyclin D1 and elevation of Bax/Bcl-2 ratio. BioMed Research International, Vol 2015, Article ID 649263. http://dx.doi.org/10.1155/2015/649263
  6. Charepalli V, Reddivari L, Radhakrishnan S, Ramakrishna Vadde, Agarwal R, Vanamala JK. (2015). Anthocyanin-containing purple-fleshed potatoes suppress colon tumorigenesis via elimination of colon cancer stem cells. Journal of Nutritional Biochemistry. Volume 26, Issue 12, Pages 1641–1649. doi: 10.1016/j.jnutbio.2015.08.005.
  7. Vadde Ramakrishna, Sriram Gopi and Oruganti H Setty (2012). Protective effect of Hemidesmus indicus extract against bromobenzene induced mitochondrial dysfunction in rat kidney. American J Chinese Medicine 40 (3): 567-80.
  8. Vadde Ramakrishna, S Rajasekhar and L. Sudarsana Reddy (2010). Isolation and purification of metalloprotease from grass pea (Lathyrus sativus) seeds. Applied Biochemistry and Biotechnology, 160: 63–71.
  9. Vadde Ramakrishna, V. Sarojamma, and L. Sudarsana Reddy (2009). Short report - Genetic predisposition to chikungunya – a blood group study in chikungunya affected families. Virology Journal, 6:77.
  10. Vadde Ramakrishna and Rama Jailkhani (2008). Oxidative stress in non-insulin dependent diabetes mellitus (NIDDM) patients. Acta Diabetologica 45(1): 41.
Conference/symposia attended (during the last five years):
Conference/symposia organized (during the last five years):
Other Information (books, patents, collaborations etc.):
  1. Dr. Julien Y. Dutheil, Max Planck Institute for Evolutionary Biology Molecular Systems Evolution Department of Evolutionary Genetics Plön -- GERMANY
  2. Dr. Jairam KP Vanamala, Dept. of Food Science, Penn State University, University-Park, State College, PA, USA