Dr. Venkata Rami Reddy Narala M.sc Ph.d
Assistant Professor
Department of Animal Sciences (Zoology)
Yogi Vemana University
KADAPA-516003, INDIA +91 9866094531
nvrr@yogivemanauniversity.ac.in, nvramireddy@gmail.com
Qualification :
• Ph.D. (Genetics) - Osmania University, Hyderabad, India.(2008)
• M.Sc. (Biotechnology) - Sri Venkateswara University, Tirupati, India.(1999) • B.Sc. (Chemistry, Botany and Zoology) - Sri Venkateswara University, Tirupati, India (1997)
• July 2009- till date: Assistant Professor, Dept. of Animal Sciences, Yogi Vemana University, KADAPA, India.
• March 2006 to September 2008: Visiting Scholar at Internal Medicine, University of Michigan, Ann Arbor, USA.
• May 2002 to March 2006: Scientist at Virchow Biotech Private Limited, Hyderabad, India
• January 2000 to May 2002: Research assistant at Blue Peter Research centre, Lepra India, Hyderabad, India.
• Life Member of Indian Immunology Society
• Life Member of Laboratory Animal Scientists Association (LASA)
• Life Member of the Indian Science Congress Association
• DST – FAST Track Young Scientist – 2012
• CPCSEA nominee for IAEC
Area/s of research interests :
Pulmonary Diseases ( asthma , fibrosis, cancer), Nuclear Receptors Signalling.
Projects undertaken :
• CSIR: “Identification novel endogenous peroxisome proliferator-activated gamma (PPARγ) ligands in adipogenesis”. (2011-2014): 25 Lakh major research grant.
• Department of Science and Technology (DST-India), FAST TRACK Young Scientist, “Role of Nitrated fatty acids in immunosupression,” (2011-2014): 20 Lakh project.
• Department of Biotechnology (DBT): Role of Nuclear Receptors on airway inflammation and remodeling. (2011-2014): 50 lakh project
• Virchow Biotech Private Limited (VBPL), Hyderabad, “Study the role of NFAs on Lung fibrosis”. (2010- 2012): 10 Lakh funding.
Achievements/Awards :
1. Visiting Scholar Fellowship to work at University of Michigan, USA—Fellowship was sponsored by Virchow Biotech Private Limited, Hyderabad from 2006-2008.
2. Young scientist award (2011) from Department of Science and Technology (DST), India
Research Scholars
Ms. Firdose Begum Shaik, Title: Role of Nuclear Receptors in airway inflammation and remodelling.
Details of significant paper publications :
1. Shaik, F.B., Panati, K., Narasimha, V.R., and Narala, V.R.* (2015). Chenodeoxycholic acid attenuates ovalbumin-induced airway inflammation in murine model of asthma by inhibiting the TH2 cytokines. Biochemical and biophysical research communications 463, 600-605. Impact Factor: 2.297
2. Shaik, F.B., Prasad, D.V., and Narala, V.R.* (2015). Role of farnesoid X receptor in inflammation and resolution. Inflammation research 64, 9-20. Impact Factor: 2.347
3. Kanumuri, R.M., Bajji, C., Tummuru, R.R., Tatireddigari, V.R., Mangamoori, L.N., Panati, K., and Narala, V.R.* (2015). Increased yield of high purity recombinant human brain natriuretic peptide by acid hydrolysis of short fusion partner in Escherichia coli. Protein expression and purification 111, 61-67. Impact Factor: 1.695
4. Subramani, P.A., Narala, V.R., Michael, R.D., Lomada, D., and Reddy, M.C. (2015). Molecular docking and simulation of Curcumin with Geranylgeranyl Transferase1 (GGTase1) and Farnesyl Transferase (FTase). Bioinformation 11, 248-253. Impact Factor: 0.5
5. Narala, V.R. *, Subramani, P.A., Narasimha, V.R., Shaik, F.B., and Panati, K. (2014). The role of nitrated fatty acids and peroxisome proliferator-activated receptor gamma in modulating inflammation. International immunopharmacology 23, 283-287. Impact Factor: 2.472
6. Gudipudi, A., Bajji, C., Kosana, R.R., Panati, K., Lomada, D., Arva Tatireddigari, V.R., and Narala, V.R.* (2014). Gene fragment polymerization for increased yield of recombinant HIV fusion inhibitor enfuvirtide. Biotechnology letters 36, 1761-1769. Impact Factor: 1.591
7. Kosana, R.R., Bajji, C., Kanumuri, R.M., Panati, K., Mangamoori, L.N., Tummuru, M.R., and Narala, V.R.* (2014). Recombinant approach for the production of HIV fusion inhibitor Enfuvirtide using Escherichia coli. Protein expression and purification 95, 136-142. Impact Factor: 1.695
8. Subramani, P.A., and Narala, V.R.* (2013). Challenges of curcumin bioavailability: novel aerosol remedies. Natural product communications 8, 121-124. Impact Factor: 1.00
9. Subramani, P.A., Panati, K., and Narala, V.R.* (2013a). Molecular docking of Glyceroneogenesis pathway intermediates with Peroxisome Proliferator- Activated Receptor-Alpha (PPAR-alpha). Bioinformation 9, 629-632. Impact Factor: 0.50
10. Subramani, P.A., Reddy, M.C., and Narala, V.R.* (2013b). The need for physiologically relevant peroxisome proliferator-activated receptor-gamma (PPAR-gamma) ligands. Endocrine, metabolic & immune disorders drug targets 13, 175-183.
11. Thippanna, M., Subramani, P.A., Lomada, D., Narala, V.R., and Reddy, M.C. (2013). A Homology Based Model and Virtual Screening of Inhibitors for Human Geranylgeranyl Transferase 1 (GGTase1). Bioinformation 9, 973-977. Impact Factor: 0.50
12. Reka, A.K., Kurapati, H., Narala, V.R., Bommer, G., Chen, J., Standiford, T.J., and Keshamouni, V.G. (2010). Peroxisome proliferator-activated receptor-gamma activation inhibits tumor metastasis by antagonizing Smad3-mediated epithelial-mesenchymal transition. Mol Cancer Ther 9, 3221-3232. Impact Factor: 6.11
13. Smith, M.R., Gangireddy, S.R., Narala, V.R., Hogaboam, C.M., Standiford, T.J., Christensen, P.J., Kondapi, A.K., and Reddy, R.C. (2010). Curcumin inhibits fibrosis-related effects in IPF fibroblasts and in mice following bleomycin-induced lung injury. American journal of physiology Lung cellular and molecular physiology 298, L616-625. Impact Factor: 4.080
14. Narala, V.R., Adapala, R.K., Suresh, M.V., Brock, T.G., Peters-Golden, M., and Reddy, R.C. (2010). Leukotriene B4 is a physiologically relevant endogenous peroxisome proliferator-activated receptor-alpha agonist. J Biol Chem 285, 22067-22074. Impact Factor: 5.00
Narala, V.R., Smith, M.R., Adapala, R.K., Ranga, R., Panati, K., Moore, B.B., Leff, T., Reddy, V.D., Kondapi, A.K., and Reddy, R.C. (2009). Curcumin is not a ligand for peroxisome proliferator-activated receptor-gamma. Gene therapy & molecular biology 13, 20-25. Impact Factor: .75
16. Reddy, R.C., Narala, V.R., Keshamouni, V.G., Milam, J.E., Newstead, M.W., and Standiford, T.J. (2008). Sepsis-induced inhibition of neutrophil chemotaxis is mediated by activation of peroxisome proliferator-activated receptor-{gamma}. Blood 112, 4250-4258. Impact Factor: 10.452
17. Sagili, K.D., Raju, R., Reddy, V.R., Anandaraj, M.P., Suneetha, S., and Suneetha, L.M. (2008). Protein phosphorylation pattern in the immune cells of leprosy affected individuals. Journal of infection in developing countries 2, 124-129. Impact Factor: 1.30
18. Narala, V.R., Ranga, R., Smith, M.R., Berlin, A.A., Standiford, T.J., Lukacs, N.W., and Reddy, R.C. (2007). Pioglitazone is as effective as dexamethasone in a cockroach allergen-induced murine model of asthma. Respiratory research 8, 90. Impact Factor: 3.40
19. Karumuri, N.N., Gangireddy, S.R., Narala, V.R., Majee, S.S., Gunwar, S., and Reddy, R.C. (2007). Simple, rapid, high-purity preparation of recombinant human platelet-derived growth factor-BB. Biotechnology letters 29, 1333-1339. Impact Factor: 1.591
20. Reddy, P.K., Reddy, S.G., Narala, V.R., Majee, S.S., Konda, S., Gunwar, S., and Reddy, R.C. (2007).Increased yield of high purity recombinant human interferon-gamma utilizing reversed phase column chromatography. Protein expression and purification 52,Impact Factor: 1.695